Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin-C/insulinlike growth factor I.

We studied somatomedin-C/insulinlike growth factor (Sm-C/IGF-I) binding to human fibroblasts in both adherent monolayers and in suspension cultures. The addition of Sm-C/IGF-I in concentrations between 0.5 and 10 ng/ml to monolayers cultures resulted in a paradoxical increase in 125I-Sm-C/IGF-I bind...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Clemmons, D R, Elgin, R G, Han, V K, Casella, S J, D'Ercole, A J, Van Wyk, J J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1986
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424558/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2422210/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112470
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