Roles of 5-Lipoxygenase and Cysteinyl-Leukotriene Type 1 Receptors in the Hematological Response to Allergen Challenge and Its Prevention by Diethylcarbamazine in a Murine Model of Asthma

Diethylcarbamazine (DEC), which blocks leukotriene production, abolishes the challenge-induced increase in eosinopoiesis in bone-marrow from ovalbumin- (OVA-) sensitized mice, suggesting that 5-lipoxygenase (5-LO) products contribute to the hematological responses in experimental asthma models. We e...

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Bibliographic Details
Published in:Mediators Inflamm
Main Authors: Masid-de-Brito, Daniela, Queto, Túlio, Gaspar-Elsas, Maria Ignez C., Xavier-Elsas, Pedro
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244945/
https://ncbi.nlm.nih.gov/pubmed/25477712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/403970
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