Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size

MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC), previously shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO-216 on cholesterol efflux capacity from J774 cells, on prebeta-1 high d...

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Veröffentlicht in:J Lipids
Hauptverfasser: Kempen, Herman J., Schranz, Dorota B., Asztalos, Bela F., Otvos, James, Jeyarajah, Elias, Drazul-Schrader, Denise, Collins, Heidi L., Adelman, Steven J., Wijngaard, Peter L. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244927/
https://ncbi.nlm.nih.gov/pubmed/25478232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/923903
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