Systemic delivery of rAAV6-microdystrophin preserves muscle function and extends lifespan in a murine model of severe muscular dystrophy

Mice carrying mutations in both the dystrophin and utrophin genes die prematurely as a consequence of severe muscular dystrophy. Here, we demonstrate that intravascular administration of recombinant adeno-associated viral (rAAV) vectors carrying a microdystrophin gene restores dystrophin expression...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Med
Main Authors: Gregorevic, Paul, Allen, James M., Minami, Elina, Blankinship, Michael J., Haraguchi, Miki, Meuse, Leonard, Finn, Eric, Adams, Marvin E., Froehner, Stanley C., Murry, Charles E., Chamberlain, Jeffrey S.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244883/
https://ncbi.nlm.nih.gov/pubmed/16819550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1439
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker