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Synthesis of α-Amino Acid Derivatives and Peptides via Enantioselective Addition of Masked Acyl Cyanides to Imines
[Image: see text] A general, asymmetric synthesis of amino acid derivatives is reported. Masked acyl cyanide (MAC) reagents are shown to be effective umpolung synthons for enantioselective additions to N-Boc-aldimines. The reactions are catalyzed by a modified cinchona alkaloid, which can function a...
Kaydedildi:
| Yayımlandı: | J Am Chem Soc |
|---|---|
| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Chemical
Society
2014
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| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4244832/ https://ncbi.nlm.nih.gov/pubmed/25366558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja510135t |
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