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Synthesis of α-Amino Acid Derivatives and Peptides via Enantioselective Addition of Masked Acyl Cyanides to Imines

[Image: see text] A general, asymmetric synthesis of amino acid derivatives is reported. Masked acyl cyanide (MAC) reagents are shown to be effective umpolung synthons for enantioselective additions to N-Boc-aldimines. The reactions are catalyzed by a modified cinchona alkaloid, which can function a...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Yang, Kin S., Rawal, Viresh H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244832/
https://ncbi.nlm.nih.gov/pubmed/25366558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja510135t
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