Brightfield Proximity Ligation Assay Reveals Both Canonical and Mixed Transforming Growth Factor-β/Bone Morphogenetic Protein Smad Signaling Complexes in Tissue Sections

Transforming growth factor-β (TGF-β) is an important regulator of cellular homeostasis and disease pathogenesis. Canonical TGF-β signaling occurs through Smad2/3–Smad4 complexes; however, recent in vitro studies suggest that elevated levels of TGF-β may activate a novel mixed Smad complex (Smad2/3-S...

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Veröffentlicht in:J Histochem Cytochem
Hauptverfasser: Flanders, Kathleen C., Heger, Christopher D., Conway, Catherine, Tang, Binwu, Sato, Misako, Dengler, Samuel L., Goldsmith, Paul K., Hewitt, Stephen M., Wakefield, Lalage M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244299/
https://ncbi.nlm.nih.gov/pubmed/25141865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1369/0022155414550163
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