The in vivo role of PtdIns(3,4,5)P(3) binding to PDK1 PH domain defined by knockin mutation

We generated homozygous knockin ES cells expressing a form of 3-phosphoinositide-dependent protein kinase-1 (PDK1) with a mutation in its pleckstrin homology (PH) domain that abolishes phosphatidylinositol 3,4,5-tris-phosphate (PtdIns(3,4,5)P(3)) binding, without affecting catalytic activity. In the...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: McManus, Edward J, Collins, Barry J, Ashby, Peter R, Prescott, Alan R, Murray-Tait, Victoria, Armit, Laura J, Arthur, J Simon C, Alessi, Dario R
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424399/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15116068/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600218
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