New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.

Reactive oxygen species, particularly hydrogen peroxide (H2O2), participate in neutrophil-mediated glomerulonephritis. However, the mechanism of H2O2 neptrotoxicity is unknown. Myeloperoxidase (MPO), a neutrophil cationic enzyme that localizes in glomeruli, can react with H2O2 and halides to form hi...

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Pubblicato in:	J Clin Invest
Autori principali:	Johnson, R J, Couser, W G, Chi, E Y, Adler, S, Klebanoff, S J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424393/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3033023/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112965
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