Population pharmacokinetics and pharmacodynamics of BYL719, a phosphoinositide 3-kinase antagonist, in adult patients with advanced solid malignancies

AIMS: The aim was to characterize the population pharmacokinetics of BYL719 in cancer patients and assess the time course of tumour response in relation to drug exposure and dosing schedule. METHODS: Plasma samples and longitudinal tumour size measurements were collected from 60 patients with advanc...

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Bibliografiske detaljer
Udgivet i:Br J Clin Pharmacol
Main Authors: De Buck, Stefan S, Jakab, Annamaria, Boehm, Markus, Bootle, Douglas, Juric, Dejan, Quadt, Cornelia, Goggin, Timothy K
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Pharmacokinetic Dynamic Relationships
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243905/
https://ncbi.nlm.nih.gov/pubmed/24617631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12378
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