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Large-scale Mutational Analysis of Kv11.1 Reveals Molecular Insights into Type 2 Long QT Syndrome

It has been suggested that deficient protein trafficking to the cell membrane is the dominant mechanism associated with type 2 Long QT syndrome (LQT2) caused by Kv11.1 potassium channel missense mutations, and that for many mutations the trafficking defect can be corrected pharmacologically. However...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Anderson, Corey L., Kuzmicki, Catherine E., Childs, Ryan R., Hintz, Caleb J., Delisle, Brian P., January, Craig T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243539/
https://ncbi.nlm.nih.gov/pubmed/25417810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6535
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