Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties

Although general anesthetics are clinically important and widely used, their molecular mechanisms of action remain poorly understood. Volatile anesthetics such as isoflurane (ISO) are thought to alter neuronal function by depressing excitatory and facilitating inhibitory neurotransmission through di...

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Publicat a:J Gen Physiol
Autors principals: Herold, Karl F., Sanford, R. Lea, Lee, William, Schultz, Margaret F., Ingólfsson, Helgi I., Andersen, Olaf S., Hemmings, Hugh C.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242807/
https://ncbi.nlm.nih.gov/pubmed/25385786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411172
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