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Silence of MCL-1 upstream signaling by shRNA abrogates multiple myeloma growth
OBJECTIVES: Multiple myeloma (MM) is an incurable B-cell cancer with accumulated clonal abnormal plasma cells in bone marrow of patients. MCL-1 (myeloid cell leukemia sequence 1) protein is an anti-apoptotic molecule in MM cells and regulated by pro-inflammatory cytokine IL-6 and downstream signalin...
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| Publicado no: | Exp Hematol Oncol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4242602/ https://ncbi.nlm.nih.gov/pubmed/25422792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2162-3619-3-27 |
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