Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT

BACKGROUND: The efficacy of artemisinin-based combination therapy (ACT) for Plasmodium falciparum malaria may be threatened by parasites with reduced responsiveness to artemisinins. Among 298 ACT-treated children from Mbita, Kenya, submicroscopic persistence of P. falciparum on day 3 posttreatment w...

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Bibliographic Details
Published in:J Infect Dis
Main Authors: Henriques, Gisela, Hallett, Rachel L., Beshir, Khalid B., Gadalla, Nahla B., Johnson, Rachel E., Burrow, Rebekah, van Schalkwyk, Donelly A., Sawa, Patrick, Omar, Sabah A., Clark, Taane G., Bousema, Teun, Sutherland, Colin J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Major Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241946/
https://ncbi.nlm.nih.gov/pubmed/24994911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu358
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