Immunologic Response to Xenogeneic gp100 DNA in Melanoma Patients: Comparison of Particle Mediated Epidermal Delivery with Intramuscular Injection

PURPOSE: Prior studies show that intramuscular (IM) injection of xenogeneic orthologues of melanosomal antigens (tyrosinase, gp100) induces CD8+ T cell responses to the syngeneic protein. To further define the optimal vaccination strategy, we conducted a pilot clinical trial comparing IM injection w...

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Publicado en:Clin Cancer Res
Autores principales: Ginsberg, Brian A., Gallardo, Humilidad F., Rasalan, Teresa S., Adamow, Matthew, Mu, Zhenyu, Tandon, Sapna, Bewkes, Barrett B., Roman, Ruth-Ann, Chapman, Paul, Schwartz, Gary, Carvajal, Richard, Panageas, Katherine S., Terzulli, Stephanie L., Houghton, Alan N., Yuan, Jianda, Wolchok, Jedd D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241567/
https://ncbi.nlm.nih.gov/pubmed/20647477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1093
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