Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas

The recognition of cancer cells by T cells can impact upon prognosis and be exploited for immunotherapeutic approaches. This recognition depends on the specific interaction between antigens displayed on the surface of cancer cells and the T cell receptor (TCR), which is generated by somatic rearrang...

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Veröffentlicht in:J Pathol
Hauptverfasser: Gerlinger, Marco, Quezada, Sergio A, Peggs, Karl S, Furness, Andrew JS, Fisher, Rosalie, Marafioti, Teresa, Shende, Vishvesh H, McGranahan, Nicholas, Rowan, Andrew J, Hazell, Steven, Hamm, David, Robins, Harlan S, Pickering, Lisa, Gore, Martin, Nicol, David L, Larkin, James, Swanton, Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2013
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Original Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241038/
https://ncbi.nlm.nih.gov/pubmed/24122851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4284
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