Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas

The recognition of cancer cells by T cells can impact upon prognosis and be exploited for immunotherapeutic approaches. This recognition depends on the specific interaction between antigens displayed on the surface of cancer cells and the T cell receptor (TCR), which is generated by somatic rearrang...

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Bibliografiske detaljer
Udgivet i:J Pathol
Main Authors: Gerlinger, Marco, Quezada, Sergio A, Peggs, Karl S, Furness, Andrew JS, Fisher, Rosalie, Marafioti, Teresa, Shende, Vishvesh H, McGranahan, Nicholas, Rowan, Andrew J, Hazell, Steven, Hamm, David, Robins, Harlan S, Pickering, Lisa, Gore, Martin, Nicol, David L, Larkin, James, Swanton, Charles
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Ltd 2013
Fag:
Original Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241038/
https://ncbi.nlm.nih.gov/pubmed/24122851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4284
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