Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas

The recognition of cancer cells by T cells can impact upon prognosis and be exploited for immunotherapeutic approaches. This recognition depends on the specific interaction between antigens displayed on the surface of cancer cells and the T cell receptor (TCR), which is generated by somatic rearrang...

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Dettagli Bibliografici
Pubblicato in:J Pathol
Autori principali: Gerlinger, Marco, Quezada, Sergio A, Peggs, Karl S, Furness, Andrew JS, Fisher, Rosalie, Marafioti, Teresa, Shende, Vishvesh H, McGranahan, Nicholas, Rowan, Andrew J, Hazell, Steven, Hamm, David, Robins, Harlan S, Pickering, Lisa, Gore, Martin, Nicol, David L, Larkin, James, Swanton, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2013
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Original Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241038/
https://ncbi.nlm.nih.gov/pubmed/24122851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4284
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