Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits

BACKGROUND: Osteoarthritis (OA) is a major health problem in the increasingly elderly population. Therefore, it is crucial to prevent and treat OA at an early stage. The present study investigated whether pamidronate disodium (PAM), a bone-loss inhibitor, can significantly prevent or reverse the pro...

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Detalhes bibliográficos
Publicado no:BMC Musculoskelet Disord
Main Authors: Lv, You, Xia, Jie-yun, Chen, Jing-yang, Zhao, Hui, Yan, Hai-cui, Yang, Han-shi, Li, Qiang, Fan, Yu-xin, Guo, Kai-jin, Chen, Xiang-yang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240862/
https://ncbi.nlm.nih.gov/pubmed/25377946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-15-370
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