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Ischemic Preconditioning Inhibits Mitochondrial Permeability Transitional Pore Opening through the PTEN/PDE4 Signaling Pathway

OBJECTIVES: Ischemic preconditioning (IPC) induces cardioprotection against ischemia-reperfusion (IR) injury by inhibiting the mitochondrial permeability transition pore (mPTP). Here, we tested the hypothesis that IPC-induced cardioprotection is mediated by the phosphatase PTEN and phosphodiesterase...

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Bibliografske podrobnosti
izdano v:Cardiology
Main Authors: Zheng, Xiaoxu, Zu, Lingyun, Becker, Lewis, Cai, Zheqing P.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240802/
https://ncbi.nlm.nih.gov/pubmed/25301476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000363646
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