Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation.

The mechanism of neutrophil activation by the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (FMLP) has been studied by pretreatment of human neutrophils with pertussis toxin. Upon stimulation with FMLP, the cytosolic-free calcium concentration, [Ca2+]i, is increased both by stimulation o...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Krause, K H, Schlegel, W, Wollheim, C B, Andersson, T, Waldvogel, F A, Lew, P D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1985
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424072/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3877077/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112109
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