A Single Chain Variant of Factor VIII Fc Fusion Protein Retains Normal In Vivo Efficacy but Exhibits Altered In Vitro Activity

Recombinant factor VIII Fc (rFVIIIFc) is a fusion protein consisting of a single B-domain-deleted (BDD) FVIII linked recombinantly to the Fc domain of human IgG1 to extend half-life. To determine if rFVIIIFc could be further improved by maintaining the heavy and light chains within a contiguous sing...

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Bibliographic Details
Published in:PLoS One
Main Authors: Buyue, Yang, Liu, Tongyao, Kulman, John D., Toby, Garabet G., Kamphaus, George D., Patarroyo-White, Susannah, Lu, Qi, Reidy, Thomas J., Mei, Baisong, Jiang, Haiyan, Pierce, Glenn F., Sommer, Jurg M., Peters, Robert T.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240654/
https://ncbi.nlm.nih.gov/pubmed/25415306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113600
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