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Biochemical and functional characterization of a recombinant monomeric factor VIII–Fc fusion protein

Background: Hemophilia A results from a deficiency in factor VIII activity. Current treatment regimens require frequent dosing, owing to the short half-life of FVIII. A recombinant FVIII–Fc fusion protein (rFVIIIFc) was molecularly engineered to increase the half-life of FVIII, by 1.5–2-fold, in sev...

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書誌詳細
主要な著者: PETERS, R T, TOBY, G, LU, Q, LIU, T, KULMAN, J D, LOW, S C, BITONTI, A J, PIERCE, G F
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Publishing Ltd 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3588154/
https://ncbi.nlm.nih.gov/pubmed/23205847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12076
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