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Biochemical and functional characterization of a recombinant monomeric factor VIII–Fc fusion protein
Background: Hemophilia A results from a deficiency in factor VIII activity. Current treatment regimens require frequent dosing, owing to the short half-life of FVIII. A recombinant FVIII–Fc fusion protein (rFVIIIFc) was molecularly engineered to increase the half-life of FVIII, by 1.5–2-fold, in sev...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Publishing Ltd
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3588154/ https://ncbi.nlm.nih.gov/pubmed/23205847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12076 |
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