Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes.

Freshly isolated human neutrophils were investigated for their ability to degrade heparan sulfate proteoglycans in the subendothelial extracellular matrix (ECM) produced by cultured corneal and vascular endothelial cells. The ECM was metabolically labeled with Na2(35S)O4 and labeled degradation prod...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Matzner, Y, Bar-Ner, M, Yahalom, J, Ishai-Michaeli, R, Fuks, Z, Vlodavsky, I
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 1985
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2997275/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112104
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