Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes.

Freshly isolated human neutrophils were investigated for their ability to degrade heparan sulfate proteoglycans in the subendothelial extracellular matrix (ECM) produced by cultured corneal and vascular endothelial cells. The ECM was metabolically labeled with Na2(35S)O4 and labeled degradation prod...

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Bibliographic Details
Main Authors: Matzner, Y, Bar-Ner, M, Yahalom, J, Ishai-Michaeli, R, Fuks, Z, Vlodavsky, I
Format: Artigo
Language:Inglês
Published: 1985
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC424062/
https://ncbi.nlm.nih.gov/pubmed/2997275
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