Pancreatic and Duodenal Homeobox Protein 1 (Pdx-1) Maintains Endoplasmic Reticulum Calcium Levels through Transcriptional Regulation of Sarco-endoplasmic Reticulum Calcium ATPase 2b (SERCA2b) in the Islet β Cell

Although the pancreatic duodenal homeobox 1 (Pdx-1) transcription factor is known to play an indispensable role in β cell development and secretory function, recent data also implicate Pdx-1 in the maintenance of endoplasmic reticulum (ER) health. The sarco-endoplasmic reticulum Ca(2+) ATPase 2b (SE...

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Vydáno v:J Biol Chem
Hlavní autoři: Johnson, Justin S., Kono, Tatsuyoshi, Tong, Xin, Yamamoto, Wataru R., Zarain-Herzberg, Angel, Merrins, Matthew J., Satin, Leslie S., Gilon, Patrick, Evans-Molina, Carmella
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239629/
https://ncbi.nlm.nih.gov/pubmed/25271154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575191
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