Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN

Mesotrypsin is an isoform of trypsin that is uniquely resistant to polypeptide trypsin inhibitors and can cleave some inhibitors rapidly. Previous studies have shown that the amyloid precursor protein Kunitz protease inhibitor domain (APPI) is a specific substrate of mesotrypsin and that stabilizati...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Pendlebury, Devon, Wang, Ruiying, Henin, Rachel D., Hockla, Alexandra, Soares, Alexei S., Madden, Benjamin J., Kazanov, Marat D., Radisky, Evette S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239628/
https://ncbi.nlm.nih.gov/pubmed/25301953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609560
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