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Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN

Mesotrypsin is an isoform of trypsin that is uniquely resistant to polypeptide trypsin inhibitors and can cleave some inhibitors rapidly. Previous studies have shown that the amyloid precursor protein Kunitz protease inhibitor domain (APPI) is a specific substrate of mesotrypsin and that stabilizati...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Pendlebury, Devon, Wang, Ruiying, Henin, Rachel D., Hockla, Alexandra, Soares, Alexei S., Madden, Benjamin J., Kazanov, Marat D., Radisky, Evette S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239628/
https://ncbi.nlm.nih.gov/pubmed/25301953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609560
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