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α-Actinin-4 Is Required for Amoeboid-type Invasiveness of Melanoma Cells

α-Actinin-4 (ACTN4), a key regulator of the actin cytoskeleton, is up-regulated in melanoma, though its role in melanoma remains speculative. We have discovered that in WM1158, a highly aggressive melanoma cell line, down-regulation of ACTN4 by shRNA induces a collagen I-dependent amoeboidal-to-mese...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Shao, Hanshuang, Li, Shaoyan, Watkins, Simon C., Wells, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239623/
https://ncbi.nlm.nih.gov/pubmed/25296750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.579185
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