Crystal Structure of Cytomegalovirus IE1 Protein Reveals Targeting of TRIM Family Member PML via Coiled-Coil Interactions

PML nuclear bodies (PML-NBs) are enigmatic structures of the cell nucleus that act as key mediators of intrinsic immunity against viral pathogens. PML itself is a member of the E3-ligase TRIM family of proteins that regulates a variety of innate immune signaling pathways. Consequently, viruses have...

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Bibliografiska uppgifter
I publikationen:PLoS Pathog
Huvudupphovsmän: Scherer, Myriam, Klingl, Stefan, Sevvana, Madhumati, Otto, Victoria, Schilling, Eva-Maria, Stump, Joachim D., Müller, Regina, Reuter, Nina, Sticht, Heinrich, Muller, Yves A., Stamminger, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239116/
https://ncbi.nlm.nih.gov/pubmed/25412268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004512
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