Characterization of Recombinant Human Cytomegaloviruses Encoding IE1 Mutants L174P and 1-382 Reveals that Viral Targeting of PML Bodies Perturbs both Intrinsic and Innate Immune Responses

PML is the organizer of cellular structures termed nuclear domain 10 (ND10) or PML-nuclear bodies (PML-NBs) that act as key mediators of intrinsic immunity against human cytomegalovirus (HCMV) and other viruses. The antiviral function of ND10 is antagonized by viral regulatory proteins such as the i...

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Publicado no:J Virol
Main Authors: Scherer, Myriam, Otto, Victoria, Stump, Joachim D., Klingl, Stefan, Müller, Regina, Reuter, Nina, Muller, Yves A., Sticht, Heinrich, Stamminger, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719593/
https://ncbi.nlm.nih.gov/pubmed/26559840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01973-15
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