The Complex I Subunit NDUFA10 Selectively Rescues Drosophila pink1 Mutants through a Mechanism Independent of Mitophagy

Mutations in PINK1, a mitochondrially targeted serine/threonine kinase, cause autosomal recessive Parkinson's disease (PD). Substantial evidence indicates that PINK1 acts with another PD gene, parkin, to regulate mitochondrial morphology and mitophagy. However, loss of PINK1 also causes complex...

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Detaylı Bibliyografya
Yayımlandı:PLoS Genet
Asıl Yazarlar: Pogson, Joe H., Ivatt, Rachael M., Sanchez-Martinez, Alvaro, Tufi, Roberta, Wilson, Emma, Mortiboys, Heather, Whitworth, Alexander J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238976/
https://ncbi.nlm.nih.gov/pubmed/25412178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004815
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