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Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study
PURPOSE: TrkB acts as an oncogenic kinase in a subset of human neuroblastomas. Lestaurtinib, a multi-kinase inhibitor with potent activity against Trk kinases, has demonstrated activity in preclinical models of neuroblastoma. METHODS: Patients with refractory high-risk neuroblastoma received lestaur...
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| Published in: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4238911/ https://ncbi.nlm.nih.gov/pubmed/21340605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1581-4 |
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