Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study

PURPOSE: TrkB acts as an oncogenic kinase in a subset of human neuroblastomas. Lestaurtinib, a multi-kinase inhibitor with potent activity against Trk kinases, has demonstrated activity in preclinical models of neuroblastoma. METHODS: Patients with refractory high-risk neuroblastoma received lestaur...

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Bibliographic Details
Published in:Cancer Chemother Pharmacol
Main Authors: Minturn, Jane E., Evans, Audrey E., Villablanca, Judith G., Yanik, Gregory A., Park, Julie R., Shusterman, Suzanne, Groshen, Susan, Hellriegel, Edward T., Bensen-Kennedy, Debra, Matthay, Katherine K., Brodeur, Garrett M., Maris, John M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238911/
https://ncbi.nlm.nih.gov/pubmed/21340605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1581-4
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