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Direct Measurement of Lipase Inhibition by Orlistat Using a Dissolution Linked In Vitro Assay
PURPOSE: To develop a bio-assay that would be able to directly test gastrointestinal and/or dissolution samples to determine lipase activity and inhibition by Orlistat. METHODS: Enzyme assays were performed with porcine pancreatic lipase and para-Nitrophenyl Palmitate (pNPP) in pH 8.0 reaction buffe...
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| Publicado no: | Clin Pharmacol Biopharm |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4238884/ https://ncbi.nlm.nih.gov/pubmed/25419492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2167-065X.1000103 |
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