G protein-coupled receptor kinase 2 moderates recruitment of THP-1 cells to the endothelium by limiting histamine-invoked Weibel-Palade body exocytosis

BACKGROUND: G protein-coupled receptors (GPCRs) are a major family of signaling molecules, central to the regulation of inflammatory responses. Their activation upon agonist binding is attenuated by GPCR kinases (GRKs), which desensitize the receptors through phosphorylation. G protein-coupled recep...

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Detaylı Bibliyografya
Yayımlandı:J Thromb Haemost
Asıl Yazarlar: Stevenson, N L, Martin-Martin, B, Freeman, J, Kriston-Vizi, J, Ketteler, R, Cutler, D F
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BlackWell Publishing Ltd 2014
Konular:
Vascular Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238739/
https://ncbi.nlm.nih.gov/pubmed/24735118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12470
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