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Weibel-Palade body size modulates the adhesive activity of its von Willebrand Factor cargo in cultured endothelial cells

Changes in the size of cellular organelles are often linked to modifications in their function. Endothelial cells store von Willebrand Factor (vWF), a glycoprotein essential to haemostasis in Weibel-Palade bodies (WPBs), cigar-shaped secretory granules that are generated in a wide range of sizes. We...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ferraro, Francesco, Mafalda Lopes da, Silva, Grimes, William, Lee, Hwee Kuan, Ketteler, Robin, Kriston-Vizi, Janos, Cutler, Daniel F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006059/
https://ncbi.nlm.nih.gov/pubmed/27576551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32473
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