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Weibel-Palade body size modulates the adhesive activity of its von Willebrand Factor cargo in cultured endothelial cells

Changes in the size of cellular organelles are often linked to modifications in their function. Endothelial cells store von Willebrand Factor (vWF), a glycoprotein essential to haemostasis in Weibel-Palade bodies (WPBs), cigar-shaped secretory granules that are generated in a wide range of sizes. We...

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Pubblicato in:Sci Rep
Autori principali: Ferraro, Francesco, Mafalda Lopes da, Silva, Grimes, William, Lee, Hwee Kuan, Ketteler, Robin, Kriston-Vizi, Janos, Cutler, Daniel F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006059/
https://ncbi.nlm.nih.gov/pubmed/27576551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32473
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