Hydrogen peroxide from cellular metabolism of cystine. A requirement for lysis of murine tumor cells by vernolepin, a glutathione-depleting antineoplastic.

The sesquiterpene lactone antineoplastic vernolepin acutely depletes murine tumor cell glutathione (GSH), and lyses the cells by an unknown mechanism that is enhanced synergistically by inhibition of GSH synthesis with buthionine sulfoximine (BSO) (Arrick et al. 1983. J. Clin. Invest. 71:258). We fo...

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izdano v:	J Clin Invest
Principais autores:	Arrick, B A, Griffo, W, Cohn, Z, Nathan, C
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical Investigation 1985
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423862/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3928682/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112008
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