Hydrogen peroxide from cellular metabolism of cystine. A requirement for lysis of murine tumor cells by vernolepin, a glutathione-depleting antineoplastic.

The sesquiterpene lactone antineoplastic vernolepin acutely depletes murine tumor cell glutathione (GSH), and lyses the cells by an unknown mechanism that is enhanced synergistically by inhibition of GSH synthesis with buthionine sulfoximine (BSO) (Arrick et al. 1983. J. Clin. Invest. 71:258). We fo...

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Bibliografische gegevens

Gepubliceerd in:	J Clin Invest
Hoofdauteurs:	Arrick, B A, Griffo, W, Cohn, Z, Nathan, C
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Clinical Investigation 1985
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423862/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3928682/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112008
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