Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models

Many protein-misfolding disorders can be modeled in the budding yeast Saccharomyces cerevisiae. Proteins such as TDP-43 and FUS, implicated in amyotrophic lateral sclerosis, and α-synuclein, implicated in Parkinson’s disease, are toxic and form cytoplasmic aggregates in yeast. These features recapit...

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Bibliographic Details
Published in:J Vis Exp
Main Authors: Jackrel, Meredith E., Tariq, Amber, Yee, Keolamau, Weitzman, Rachel, Shorter, James
Format: Artigo
Language:Inglês
Published: MyJove Corporation 2014
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238040/
https://ncbi.nlm.nih.gov/pubmed/25407485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/52089
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