Targeted Reduction of Vascular Msx1 and Msx2 Mitigates Arteriosclerotic Calcification and Aortic Stiffness in LDLR-Deficient Mice Fed Diabetogenic Diets

When fed high-fat diets, male LDLR(−/−) mice develop obesity, hyperlipidemia, hyperglycemia, and arteriosclerotic calcification. An osteogenic Msx-Wnt regulatory program is concomitantly upregulated in the vasculature. To better understand the mechanisms of diabetic arteriosclerosis, we generated SM...

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Veröffentlicht in:Diabetes
Hauptverfasser: Cheng, Su-Li, Behrmann, Abraham, Shao, Jian-Su, Ramachandran, Bindu, Krchma, Karen, Bello Arredondo, Yoanna, Kovacs, Attila, Mead, Megan, Maxson, Robert, Towler, Dwight A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2014
Schlagworte:
Complications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237989/
https://ncbi.nlm.nih.gov/pubmed/25056439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0326
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