Vascular Smooth Muscle LRP6 Limits Arteriosclerotic Calcification in Diabetic LDLR-/- Mice by Restraining Noncanonical Wnt Signals

RATIONALE: Wnt signaling regulates key aspects of diabetic vascular disease. OBJECTIVE: We generated SM22-Cre;LRP6(fl/fl);LDLR-/- mice to determine contributions of Wnt co-receptor LRP6 in the vascular smooth muscle lineage (VSM) of male LDLR-null mice, a background susceptible to diet (HFD) - induc...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Cheng, Su-Li, Ramachandran, Bindu, Behrmann, Abraham, Shao, Jian-Su, Mead, Megan, Smith, Carolyn, Krchma, Karen, Arredondo, Yoanna Bello, Kovacs, Attila, Kapoor, Kapil, Brill, Laurence M., Perera, Ranjan, Williams, Bart O., Towler, Dwight A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490945/
https://ncbi.nlm.nih.gov/pubmed/26034040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.306712
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