Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles

BACKGROUND: Nanoparticle pharmacokinetics and biological effects are influenced by several factors. We assessed the effects of amorphous SiO(2) coating on the pharmacokinetics of zinc oxide nanoparticles (ZnO NPs) following intratracheal (IT) instillation and gavage in rats. METHODS: Uncoated and Si...

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Bibliografiske detaljer
Udgivet i:Part Fibre Toxicol
Main Authors: Konduru, Nagarjun V, Murdaugh, Kimberly M, Sotiriou, Georgios A, Donaghey, Thomas C, Demokritou, Philip, Brain, Joseph D, Molina, Ramon M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237897/
https://ncbi.nlm.nih.gov/pubmed/25183210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12989-014-0044-6
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