GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy

Seizures frequently accompany gliomas and often escalate to peritumoral epilepsy. Previous work revealed the importance of tumor-derived excitatory glutamate (Glu) release mediated by the cystine-glutamate transporter (SXC) in epileptogenesis. We now show a novel contribution of GABAergic disinhibit...

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Argitaratua izan da:Glia
Egile Nagusiak: Campbell, Susan L., Robel, Stefanie, Cuddapah, Vishnu A., Robert, Stephanie, Buckingham, Susan C., Kahle, Kristopher T., Sontheimer, Harald
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237714/
https://ncbi.nlm.nih.gov/pubmed/25066727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22730
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