Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylase.

In cultured hepatocytes conversion of [4-14C]cholesterol into bile acids was dose dependently reduced by the antimycotic drug ketoconazole, giving half-maximal inhibition at 10 microM ketoconazole in rat hepatocytes and at 1 microM in human hepatocytes. No change was observed in the ratio of produce...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Princen, H M, Huijsmans, C M, Kuipers, F, Vonk, R J, Kempen, H J
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1986
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423762/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3760182/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112662
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