Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylase.
In cultured hepatocytes conversion of [4-14C]cholesterol into bile acids was dose dependently reduced by the antimycotic drug ketoconazole, giving half-maximal inhibition at 10 microM ketoconazole in rat hepatocytes and at 1 microM in human hepatocytes. No change was observed in the ratio of produce...
Kaydedildi:
| Yayımlandı: | J Clin Invest |
|---|---|
| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Clinical Investigation
1986
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423762/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3760182/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112662 |
| Etiketler: |
Etiket eklenmemiş, İlk siz ekleyin!
|