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Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat

Cholesterol 7 alpha-hydroxylase, the rate-determining enzyme in the bile acid biosynthesis pathway, is regulated in a negative feedback manner by hydrophobic bile salts returning to the liver via the portal circulation. The role of cholesterol in the regulation of cholesterol 7 alpha-hydroxylase and...

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Autori principali: MP Jones, WM Pandak, DM Heuman, JY Chiang, PB Hylemon, ZR Vlahcevic
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 1993-06-01
Serie:Journal of Lipid Research
Accesso online:http://www.sciencedirect.com/science/article/pii/S0022227520396759
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