Cobalamin inactivation decreases purine and methionine synthesis in cultured lymphoblasts.

The megaloblastic anemia of cobalamin deficiency appears secondary to decreased methionine synthetase activity. Decreased activity of this enzyme should cause 5-methyltetrahydrofolate to accumulate intracellularly, and consequently, decrease purine and DNA synthesis; this is the basis of the "methyl...

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Dades bibliogràfiques

Publicat a:	J Clin Invest
Autor principal:	Boss, G R
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Clinical Investigation 1985
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423748/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2862163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111948
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