Cobalamin inactivation decreases purine and methionine synthesis in cultured lymphoblasts.

The megaloblastic anemia of cobalamin deficiency appears secondary to decreased methionine synthetase activity. Decreased activity of this enzyme should cause 5-methyltetrahydrofolate to accumulate intracellularly, and consequently, decrease purine and DNA synthesis; this is the basis of the "methyl...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	J Clin Invest
1. Verfasser:	Boss, G R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1985
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423748/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2862163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111948
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!