Cobalamin inactivation decreases purine and methionine synthesis in cultured lymphoblasts.
The megaloblastic anemia of cobalamin deficiency appears secondary to decreased methionine synthetase activity. Decreased activity of this enzyme should cause 5-methyltetrahydrofolate to accumulate intracellularly, and consequently, decrease purine and DNA synthesis; this is the basis of the "methyl...
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| Publié dans: | J Clin Invest |
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| Auteur principal: | |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
1985
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423748/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2862163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111948 |
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