Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2

Myofiber necrosis and fibrosis are hallmarks of Duchenne muscular dystrophy (DMD), leading to lethal weakness of the diaphragm. Macrophages (MPs) are required for successful muscle regeneration, but the role of inflammatory monocyte (MO)-derived MPs in either promoting or mitigating DMD is unclear....

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Dettagli Bibliografici
Pubblicato in:EMBO Mol Med
Autori principali: Mojumdar, Kamalika, Liang, Feng, Giordano, Christian, Lemaire, Christian, Danialou, Gawiyou, Okazaki, Tatsuma, Bourdon, Johanne, Rafei, Moutih, Galipeau, Jacques, Divangahi, Maziar, Petrof, Basil J
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2014
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237472/
https://ncbi.nlm.nih.gov/pubmed/25312642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201403967
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