Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2

Myofiber necrosis and fibrosis are hallmarks of Duchenne muscular dystrophy (DMD), leading to lethal weakness of the diaphragm. Macrophages (MPs) are required for successful muscle regeneration, but the role of inflammatory monocyte (MO)-derived MPs in either promoting or mitigating DMD is unclear....

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Mojumdar, Kamalika, Liang, Feng, Giordano, Christian, Lemaire, Christian, Danialou, Gawiyou, Okazaki, Tatsuma, Bourdon, Johanne, Rafei, Moutih, Galipeau, Jacques, Divangahi, Maziar, Petrof, Basil J
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237472/
https://ncbi.nlm.nih.gov/pubmed/25312642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201403967
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